Epidermis yumye bivuze ko inzitizi yuruhu ihungabanye, lipide zabuze, proteyine zigabanuka

Nyuma yo kwangirika gukabije cyangwa karande kuri bariyeri ya epidermal, uburyo bwo gusana bwihuse bwuruhu bizihutisha umusaruro wa keratinocytes, bigabanya igihe cyo gusimbuza selile epidermal, kandi bigahuza no gukora no kurekura cytokine, bikaviramo hyperkeratose no gutwika byoroheje uruhu . Ibi kandi biranga ibimenyetso byuruhu rwumye.

Gutwika kwaho birashobora kandi gukaza umwuma wuruhu, mubyukuri, gusenyuka kwinzitizi ya epidermal bitera guhuza no kurekura urukurikirane rwa cytokine itera inflammatory, nka IL-1he TNF, kugirango ingirabuzimafatizo z'umubiri za fagocyitike, cyane cyane neutrophile. Nyuma yo gukururwa ahantu humye, nyuma yo kugera aho igana, neutrophile isohora leukocyte elastase, cathepsin G, protease 3, na kolagenase mumyanya ikikije, hanyuma ikora kandi ikungahaza protease muri keratinocytes. Ingaruka zishobora guterwa nibikorwa bya protease birenze: 1. Kwangirika kwakagari; 2. Kurekura cytokine itera umuriro; 3. Kwangirika imburagihe byimikorere ya selile-selile itera mitito ya selile. Igikorwa cya poroteyine ya poroteyine mu ruhu rwumye, gishobora no kugira ingaruka ku mitsi yumva muri epidermis, ifitanye isano na pruritus n'ububabare. Gukoresha ingingo ya acide tranexamic na α1-antitrypsin (protease inhibitor) kuri xerose ni byiza, byerekana ko xeroderma ifitanye isano nibikorwa bya enzyme ya proteolyique.

Epidermis yumye bivuze koinzitizi y'uruhu irahungabanye, lipide ziratakara, proteyine ziragabanuka, nibintu byokongeza byaho birekurwa.Kuma uruhu rwatewe no kwangirika kwa bariyeriitandukanye no gukama biterwa no kugabanuka kwa sebum, kandi ingaruka zo kongeramo lipide yoroshye akenshi zinanirwa kugera kubiteganijwe. Amavuta yo kwisiga yatunganijwe kugirango yangiritse kuri bariyeri ntagomba gusa kongeramo ibintu bitera ububobere bwa stratum corneum, nka ceramide, ibintu bisanzwe bitanga amazi, nibindi, ariko nanone hitabwa ku ngaruka ziterwa na antioxydeant, anti-inflammatory, na anti-selile, bityo bikagabanya itandukaniro ryuzuye. ya keratinocytes. Inzitizi yumye yumubiri ikunze guherekezwa na pruritus, kandi hagomba gutekerezwa kongeramo ibikorwa bya antipruritis.