Uruhu rwumye rw'uruhu rusobanura ko uruhu ruhungabanye, ibinure bitakaza, poroteyine zikagabanuka

Nyuma yo kwangirika gukabije cyangwa guhoraho ku ruhu, uburyo bwo gusana uruhu bwihuta butuma keratinocytes zikorwa, bugabanye igihe cyo gusimbuza uturemangingo tw’uruvange rw ...

Ubwivumbure bw'aho hantu bushobora kandi kongera ubwumye bw'uruhu, mu by'ukuri, gusenyuka kw'urukuta rw'inyuma rw'uruhu bituma habaho ikorwa n'irekurwa ry'uruhererekane rwa cytokine zitera ububyimbirwe, nka IL-1he TNF, bityo uturemangingo tw'ubudahangarwa bw'umubiri, cyane cyane neutrophils, turangirika. Nyuma yo gukururwa n'aho humutse, nyuma yo kugera aho uruhu ruherereye, neutrophils zisohora leukocyte elastase, cathepsin G, protease 3, na collagenase mu ngingo zikikije, kandi zigakora kandi zikongera porotease muri keratinocytes. Ingaruka zishobora guterwa n'imikorere myinshi ya protease: 1. Kwangirika k'uturemangingo; 2. Gusohora cytokine zitera ububyimbirwe; 3. Kwangirika mbere y'igihe kw'ingirabuzimafatizo hagati y'uturemangingo n'uturemangingo bituma imiterere y'uturemangingo itera imitose. Imikorere ya enzymee ya proteolytic mu ruhu rwumye, ishobora no kugira ingaruka ku mitsi yumva mu ruhu, ifitanye isano no gushyuha no kubabara. Gukoresha aside tranexamic na α1-antitrypsin (irinda protease) kuri xerosis ni ingirakamaro, bigaragaza ko xeroderma ifitanye isano n'imikorere ya enzymee ya proteolytic.

Epidermis yumye bivuze kouruhu rwangiritse, ibinure biratakara, poroteyine ziragabanuka, kandi ibintu bitera ububabare mu mubiri birarekurwa.Kuma k'uruhu guterwa no kwangirika kw'uruzitirobitandukanye no kuma kw'uruhu guterwa no kugabanuka kw'imisemburo y'amaraso, kandi ingaruka zo kongeramo amavuta y'uruhu akenshi ntizishobora kugera ku byo umuntu yari yiteze. Amavuta yo kwisiga yakozwe kugira ngo yongere ubushyuhe ku ruhu ntabwo agomba gusa kongeramo ibintu bigabanya ubushyuhe ku ruhu, nka ceramide, ibintu bigabanya ubushyuhe ku ruhu, nibindi, ahubwo agomba no kwita ku ngaruka zo kwica udukoko, kurwanya ubushyuhe, no kurwanya igabanyuka ry'uturemangingo, bityo bigabanye itandukaniro risesuye rya keratinocytes. Kuma kw'uruhu ku ruhu akenshi biherekezwa no gukurura, kandi hagomba kwitabwaho kongeramo imiti igabanya ubushyuhe.