Ibyuma byo kwisiga by'umweru n'ihinduka ry'ibara ry'uruhu

Ibyuma byo kwisiga byera kandiIbara ry'uruhuIhinduka ry'umubiri

Melanine anabolism igabanyijemo ibihe bitandukanye. Abahanga mu bya siyansi bizera ko bishoboka kwiga ibintu bikora umweru no gukora mu bihe bitandukanye by'imikorere y'umubiri.

(1) Intambwe ya mbere yo gukora melanin

① Bibangamira uburyo tyrosinase ikorwamo cyangwa igashyirwamo glycosylation; ② Bibuza abahanga mu kugenzura ikorwa rya tyrosinase; ③ Gugenzura tyrosinase nyuma yo kuyihindura.

(2) Igihe cyo gukora Melanine
Nk’inzobere y’ingenzi n’inzobere igabanya igipimo cyo gukora melanin, inzobere za tyrosinase ni zo zigamije ubushakashatsi n’iterambere muri iki gihe. Kubera ko ibintu byinshi byo kugabanya umweru nka phenol na catechol bisa n’imiterere ya tyrosine na dopa, inzobere zasuzumwe akenshi zishyirwa mu byiciro nk’inzobere zidahangana cyangwa zirwanya tyrosinase.

(3) Intambwe ya nyuma yo gukora melanin

①Ibuza ikwirakwizwa rya melanosome; ibintu bifite ingaruka zo gukumira serine protease, nka rwj-50353, birinda burundu ibara ry’uruhu riterwa na UBV; inhibitor ya soya trypsin igira ingaruka nziza ku buryo bugaragara ku kwera ariko nta ngaruka igira ku burozi bw’uturemangingo tw’uruhu; Niacinamide, ishobora kubangamira ikwirakwizwa rya melanocytes hagati ya melanocytes na keratinocytes; ② Gukwirakwira kwa melanin no gukora metabolism, aside α-hydroxy, aside irike y’uburemere na aside retinoic, bitera imbaraga kuvugurura uturemangingo kandi bigatera keratinocytes za melaninized kuvaho.

Ni ngombwa kumenya ko ubushakashatsi n'ikoreshwa ry'ibintu bihindura umweru bishingiye ku mikorere ya melanin yavuzwe haruguru bidakwiye mu gukumira no kuvura plaque zo mu bwoko bwa senile. Kubera ko uburyo bwo gukora plaque zo mu bwoko bwa senile bufitanye isano no gukora kwa lipofuscin, ibintu birwanya oxidative bikunze gukoreshwa mu gutinza no gusubiza inyuma plaque zo mu bwoko bwa senile.